|
KMID : 0903520090520040327
|
|
Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 4 p.327 ~ p.330
|
|
|
Antimicrobial Effects of Anthracene and Its Derivatives against Intestinal Bacteria
|
|
Kim Min-Gi
Jeong Eun-Young
Lee Hoi-Seon
|
|
|
Abstract
|
|
|
|
The growth-inhibitory effects of anthracene were determined against intestinal bacteria, and compared with those of its derivatives for a better understanding of structure-activity relationships. The Growth inhibiting activity was shown to vary the chemical, dose, and bacterial strain tested. In tests with Clostridium perfringens, anthracence evidenced strong (+++) and moderate (++) growth inhibition at 1.0 and 0.25 mg/disc, respectively, but exhibited no growth inhibition effects against lactic-acid producing bacteria and E. coli. In our study of structureactivity relationships, anthracene-9-carboxylic acid evidenced strong (+++) and moderate (++) growth inhibition at 1.0 and 0.25 mg/disc, respectively, but anthracence-9-carboxaldehyde, anthrone, and 9-(hydroxymethyl)-anthracene exhibited no growth-inhibitory effects against six intestinal bacteria. In conclusion, the growth-inhibitory activities of anthracene and anthracene-9-carboxylic acid against C. perfringens may be indicative of at least one of these pharmacological actions. Furthermore, anthracene and anthracene-9-carboxylic acid may prove useful as prospective therapeutics for the treatment of gastrointestinal diseases caused by perfringens.
|
|
|
KEYWORD
|
|
|
anthracene, anthracene-9-carboxylic acid, antimicrobial activity, intestinal bacteria
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|